Plain-English translation of NCT05756257 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Researchers at Yale University are studying how unstable blood pressure in the hours and days after a stroke affects a patient's recovery. This study will measure blood pressure carefully and use brain imaging to see if blood pressure swings are connected to how much brain damage occurs and how well patients recover from stroke.
Past research suggests that big swings in blood pressure after a stroke are linked to worse outcomes—like lasting disability or death—but most of that research was done by looking backward at old records. This study will track patients prospectively (as the stroke happens) to understand the problem better and test whether certain blood pressure medications can help reduce these dangerous swings.
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If you join this study, researchers will measure your blood pressure regularly and carefully during your hospital stay—multiple times per day over several days. You'll also have a portable MRI scan of your brain to see the extent of damage from the stroke, and doctors will use a bedside eye scan to check your nervous system's response. The study will gather information about your recovery over time to see if blood pressure stability is connected to how well you heal.
AI-generated summary from trial data · Jun 13, 2026 · Not medical advice
United States
Sponsor
Yale University
Collaborators
University of Chicago, Massachusetts General Hospital
Enrollment target
~150 participants
Started
July 2024
Primary completion
July 2026
This trial's estimated completion date has passed — the record may not be fully up to date.
Age range
18 Years and older
Last updated on clinicaltrials.gov in May 2026.
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Central contact
Adam de Havenon, MD
Yale University
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