Plain-English translation of NCT05757791 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Read our Major Depressive Disorder research guide →Phase 2 — Testing in a bigger group (up to a few hundred people) to see if the treatment actually works and is still safe.
This trial is testing , a medication normally used to help manage blood sugar in people with diabetes, to see if it might also help reduce depression symptoms. The researchers believe this medication may work for depression by helping the brain produce ketone bodies, which are an alternative energy source. They want to understand whether this energy source could improve mood in people with major depression.
Current depression treatments don't work well for everyone, and some people need new options. This medication has some properties that researchers think might benefit the brain in ways that could ease depression—so they want to test whether this approach actually works.
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If you join this study, you will take the medication daily for 6 weeks total—starting at a lower dose for 2 weeks, then increasing to a higher dose for the remaining 4 weeks. You'll take it each morning, with or without food. You'll attend follow-up visits where researchers will check how you're doing and measure any changes in your depression symptoms. The study is small (only 16 people) and takes place at NYU Langone Health.
AI-generated summary from trial data · Jul 5, 2026 · Not medical advice
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