Plain-English translation of NCT05758688 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Phase 2 — Testing in a bigger group (up to a few hundred people) to see if the treatment actually works and is still safe.
This trial is testing whether proton radiation therapy—a focused type of radiation delivered with precision to the pelvis—can help treat gynecologic cancers (cervical, uterine, and endometrial cancer) after surgery. Proton therapy is designed to target cancer cells while reducing exposure to healthy tissue nearby. The study will include about 25 patients from Penn Medicine locations in Pennsylvania and New Jersey.
Standard radiation therapy can sometimes harm healthy organs near the cancer site. Proton therapy may be gentler on the body while still effectively treating remaining cancer cells, which could mean fewer side effects for patients who need radiation after gynecologic cancer surgery.
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You would receive proton radiation therapy directed at your whole pelvis as an outpatient, typically visiting a radiation center five days a week. The treatment course lasts several weeks, with daily doses carefully planned to target the area where your cancer was removed. Your medical team will monitor you throughout treatment to watch for any side effects and ensure the therapy is working as intended.
AI-generated summary from trial data · Jun 13, 2026 · Not medical advice
United States