Take a nightly injection to help prevent nighttime low blood sugar episodes

Back to Type 1 Diabetes Mellitus With Hypoglycemia trials

What is this trial?

This trial is testing whether ZT-01, a medication you inject before bedtime, can help prevent low blood sugar episodes that happen at night in people with type 1 diabetes. The medication works by increasing the amount of a hormone called glucagon in your body when your blood sugar drops too low. Researchers want to know if this treatment can reduce how many nighttime low blood sugar episodes you experience and whether it is safe to use.

Nighttime low blood sugar is a serious and common problem for people with type 1 diabetes—it can be dangerous and scary, and it disrupts sleep. This medication is being tested because it may help your body naturally prevent these dangerous episodes from happening in the first place.

Do you qualify?

You likely qualify if…

you have had type 1 diabetes for at least 5 years
you regularly experience low blood sugar episodes at night (at least 1% of the time your blood sugar drops below 54 mg/dL)
your overall blood sugar control (measured by HbA1c) is 10.0% or lower
your body mass index is between 18.5 and 33 kg/m²

You likely don't qualify if…

you have been hospitalized more than once for diabetic ketoacidosis in the past 6 months
you have had a severe low blood sugar episode requiring someone else's help in the past 4 weeks, or more than 2 in the past 3 months
you have kidney disease or abnormal liver function
you have been diagnosed with certain hormone-related conditions like pheochromocytoma, insulinoma, acromegaly, or Cushing's disease

What participation looks like

You will wear a continuous glucose monitor to track your blood sugar throughout the study. Over about 4 months, you will have two separate 4-week periods where you inject either the medication or a placebo (fake injection) before bed each night—you won't know which one you're getting. You'll continue using your own insulin and blood sugar management as usual, keep a simple evening diary, and upload your glucose data daily. You'll have about 6 study visits and 2 phone calls with the research team to check on your progress and safety.

Testing a new injection to prevent low blood sugar at night in type 1 diabetes

What is this trial?

Do you qualify?

What participation looks like

Trial locations(46 sites)