Plain-English translation of NCT05763966 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
This is a research study that looks at how the brain changes in people experiencing early psychosis or at high risk for developing psychosis. Researchers use advanced brain imaging called PET scans along with MRI scans, blood tests, and other medical assessments to understand what happens in the brain during these conditions. The study follows participants over several years to track how their brain and symptoms change over time.
Psychosis is a serious mental health condition, but doctors still don't fully understand what causes it or how the brain changes during early stages. This research aims to identify brain changes that might help doctors diagnose and treat psychosis earlier and more effectively.
You likely qualify if…
You likely don't qualify if…
If you qualify, you'll visit the research clinic for baseline testing that includes brain imaging scans (PET and MRI), blood tests, cognitive testing, heart rate monitoring, and a lumbar puncture (spinal tap) to collect fluid for analysis. If you're in the early psychosis or high-risk group, you'll return for repeat testing after 1 year (including another PET scan), and then again at 3 and 5 years. The initial visit takes several hours, and follow-up visits are similar but may be slightly shorter.
AI-generated summary from trial data · Jun 14, 2026 · Not medical advice
Sweden
Sponsor
Uppsala University
Collaborators
Uppsala University Hospital
Enrollment target
~120 participants
Started
April 2023
Primary completion
December 2026
Age range
18 Years – 40 Years
Last updated on clinicaltrials.gov in February 2025.
Reach out to the team running this trial. Response times vary — some teams are faster than others.
Central contact
Simon Cervenka, MD, PhD
Uppsala University
Tell us you're interested and we'll help connect you with the research team. We'll walk you through what to expect first — no email needed to get started.