Plain-English translation of NCT05764733 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Phase 4 — The treatment has already been approved. Researchers are tracking how it works in a large number of people over time.
This trial is testing whether exercise combined with alendronate (a medication that strengthens bones) can protect your bones when you're trying to lose weight. Researchers know that weight loss can weaken bones, especially in older adults. This study will compare exercise alone, the medication alone, exercise plus the medication, and a control group to see which approach works best.
When older adults lose weight, their bones often become weaker and more fragile, which increases the risk of fractures. Researchers want to find the best way to protect bone strength during weight loss using exercise and this medication.
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You will join a group-based weight loss program that lasts 12 months. Everyone participates in the same dietary counseling and weight loss support. You will be randomly assigned to one of four groups: exercise plus medication, exercise plus placebo, medication alone, or placebo alone. Throughout the year, you'll have regular visits where your bones are measured using imaging scans (X-ray and CT scans), and you'll complete follow-up assessments to track changes in your bone strength and overall health.
AI-generated summary from trial data · Jun 13, 2026 · Not medical advice
United States
Phase
Post-approval monitoring
Sponsor
Wake Forest University Health Sciences
Collaborators
National Institute on Aging (NIA)
Enrollment target
~900 participants
Started
June 2023
Primary completion
January 2028
Age range
60 Years and older
Last updated on clinicaltrials.gov in June 2026.
Reach out to the team running this trial. Response times vary — some teams are faster than others.
Central contact
Christa Todoroff Calderone, M.S.
Wake Forest University Health Sciences
Tell us you're interested and we'll help connect you with the research team. We'll walk you through what to expect first — no email needed to get started.