Plain-English translation of NCT05766410 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Read our Breast Cancer research guide →Phase 2 — Testing in a bigger group (up to a few hundred people) to see if the treatment actually works and is still safe.
This trial is testing three FDA-approved breast cancer medications—, , and —to see which one best activates your immune system to fight cancer. Each medication will be paired with hormone therapy and given for 12 weeks before surgery. The goal is to understand why these medicines work differently in some patients, which could help doctors choose the best treatment for you in the future.
All three of these medications help patients live longer when combined with hormone therapy, but doctors don't fully understand why some work better than others for overall survival. This trial will compare how each medication affects your body's immune system and the tumor microenvironment, which may explain these differences and lead to better treatment choices.
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You will be randomly assigned to take one of the three medication combinations with hormone therapy for 12 weeks before your scheduled surgery. During this time, you'll visit the clinic for check-ins and provide tissue samples from your tumor, blood samples, and stool samples at three timepoints: before treatment starts, after 2 weeks of treatment, and after 12 weeks before surgery. Researchers will analyze these samples to understand how each medication affects your immune system.
AI-generated summary from trial data · Jun 30, 2026 · Not medical advice
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