Plain-English translation of NCT05769348 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
This study doesn't follow the usual testing phases — it may be an observational study or a different type of research.
This research trial is investigating a treatment called HD-tDCS (high-definition transcranial direct current stimulation) — a non-invasive technique that delivers mild electrical stimulation to specific areas of the brain. Researchers believe this stimulation may help reduce how often people with chronic migraines get headaches by affecting the brain's pain control systems. The study will compare whether stimulating one side of the brain, both sides, or using a sham (placebo) treatment works best.
Chronic migraines affect millions of people and current treatments don't work well enough for everyone. This trial exists to explore whether this new type of brain stimulation offers hope for patients who haven't found relief with traditional medications.
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You will visit the University of Michigan several times for medical scans (MRI and PET imaging) and to receive treatment. If you are in one of the active treatment groups, you'll come in for 20 short sessions (20 minutes each) over 4 weeks, where the brain stimulation device is placed on your scalp — sessions are Monday through Friday. If you're in the sham group, you'll receive brief stimulation at the start and end of each session. All participants will have follow-up visits with repeat scans to see how the treatment affected your migraines. Additionally, about 20 people with less frequent migraines will join as a comparison group and only complete the scan visits without receiving treatment.
AI-generated summary from trial data · Jul 1, 2026 · Not medical advice
United States