Testing a vitamin supplement combined with two cancer medications for advanced colorectal cancer

This trial is testing whether adding vitamin E to two cancer-fighting medications—fruquintinib and tislelizumab—can help people whose colorectal cancer has spread and stopped responding to standard treatments. Fruquintinib works by stopping tumors from growing new blood vessels, while tislelizumab helps your immune system fight cancer cells. The researchers believe that combining vitamin E with these two medications might improve outcomes better than either treatment alone.

Standard colorectal cancer treatments do not work for everyone, and some patients' cancers continue to grow or come back. Early research suggests that combining the medication with immune-boosting treatments shows promise, so researchers want to see if adding vitamin E—which has natural anti-inflammatory and antioxidant properties—could make this combination even more effective.