Plain-English translation of NCT05774678 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Read our Breast Cancer research guide →Phase 3 — Testing in thousands of people, comparing the treatment against what doctors currently use. This is the last big step before approval.
This study compares two different ways of giving radiation therapy before mastectomy (breast removal surgery) and breast reconstruction. One approach uses fewer, stronger radiation doses given over a shorter time (hypofractionated), while the other uses the traditional approach of more frequent, smaller doses (conventionally fractionated). Researchers want to see which approach leads to better satisfaction with the reconstructed breast and fewer side effects.
Currently, patients receiving radiation before breast reconstruction often experience complications like scarring and changes in how the reconstructed breast looks and feels. This trial aims to find out whether the shorter radiation schedule might reduce these problems while still effectively treating the cancer.
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You will be randomly assigned to receive either the shorter or longer radiation schedule before your planned mastectomy and reconstruction surgery. You'll attend regular radiation appointments over several weeks, then undergo your mastectomy and breast reconstruction. The study will follow you for at least 18 months after your surgery, with visits to check your healing, take photos of your reconstructed breast, and complete surveys about your satisfaction and quality of life. Researchers will also collect tissue samples and blood samples to study how radiation affects breast tissue at a microscopic level.
AI-generated summary from trial data · Jun 27, 2026 · Not medical advice
United States