Plain-English translation of NCT05775471 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Phase 2 — Testing in a bigger group (up to a few hundred people) to see if the treatment actually works and is still safe.
This trial is testing a combination of two drugs — and — given before surgery to remove your kidney and ureter (the tube that drains urine), followed by additional after surgery. The goal is to shrink the cancer before surgery and reduce the chance that cancer comes back later.
Upper tract urothelial cancer is aggressive and often returns even after surgery. Researchers believe that giving immunotherapy drugs before surgery may help destroy cancer cells and improve long-term survival for people with this high-risk disease.
You likely qualify if…
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You will receive the two medications by intravenous infusion (through an IV) on a set schedule before your surgery. After your surgeon removes your kidney and ureter, you will receive additional doses of one of the medications. Throughout the study, you will have imaging scans, blood and urine samples collected, and tissue samples taken to help researchers understand how well the treatment is working and predict outcomes.
AI-generated summary from trial data · Jul 18, 2026 · Not medical advice
United States