Plain-English translation of NCT05775627 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
This study doesn't follow the usual testing phases — it may be an observational study or a different type of research.
This research study is investigating how chronic sleep deprivation — getting only 5.5 hours of sleep per night instead of the recommended 8 hours — affects your body's metabolism, including weight gain, food choices, and blood sugar control. Researchers want to understand the specific biological mechanisms that link poor sleep to obesity and diabetes, which affect nearly half of all Americans. The study will compare how your body responds during periods of restricted sleep versus normal sleep.
Nearly half of Americans struggle with obesity and diabetes, costing the healthcare system over $327 billion annually. While scientists know that chronic short sleep contributes to these diseases, they don't yet understand exactly how sleep deprivation leads to weight gain and blood sugar problems — especially since the body should theoretically lose weight when sleeping less and staying awake longer. This study aims to uncover those missing biological mechanisms so doctors can better prevent and treat these conditions.
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You would participate in two separate laboratory visits, living on an unusual 20-hour day where you experience either 5.5 hours of sleep or 8 hours of sleep. During each visit, you would have unlimited access to meals (provided at about 130–150% of your normal daily calories) to see how your sleep schedule affects your eating patterns and food choices. Before and between visits, you would maintain a normal 8-hour sleep schedule at home and follow a controlled diet, with your sleep monitored using a special watch and sleep logs. The entire study involves about 1 week of home monitoring before each laboratory visit.
AI-generated summary from trial data · Jun 19, 2026 · Not medical advice
United States
Sponsor
Oregon Health and Science University
Enrollment target
~20 participants
Started
December 2023
Primary completion
June 2027
Age range
18 Years – 40 Years
Last updated on clinicaltrials.gov in April 2024.
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Central contact
Andrew McHill, PhD
Oregon Health and Science University
Tell us you're interested and we'll help connect you with the research team. We'll walk you through what to expect first — no email needed to get started.