Plain-English translation of NCT05776563 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Read our Diabetes Mellitus, Type 2 research guide →This study doesn't follow the usual testing phases — it may be an observational study or a different type of research.
Researchers want to understand how uncontrolled type 2 diabetes affects how the brain uses glucose (blood sugar). This trial will measure brain glucose transport in people with poorly controlled diabetes, then repeat those measurements after 12 weeks of improved diabetes management to see if the changes can be reversed.
High blood sugar from uncontrolled diabetes may damage how the brain processes glucose, but doctors don't yet know if this damage is permanent or if it can improve with better blood sugar control. This study aims to answer that question.
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You'll start by wearing a continuous glucose monitor for 2 weeks to track your blood sugar. Then you'll have a brain scan (MRS) at the beginning of the study. Over the next 12 weeks, you'll attend visits with your diabetes care team and a nutritionist to help you better control your blood sugar. At week 12, you'll have another brain scan to see if your brain glucose transport has improved. The study lasts about 14 weeks total.
AI-generated summary from trial data · Jun 1, 2026 · Not medical advice
United States
Sponsor
Yale University
Collaborators
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Enrollment target
~24 participants
Started
July 2024
Primary completion
May 2027
Age range
18 Years – 60 Years
Last updated on clinicaltrials.gov in January 2025.
Reach out to the team running this trial. Response times vary — some teams are faster than others.
Central contact
Elizabeth Sanchez Rangel, MD
Yale University
Tell us you're interested and we'll help connect you with the research team. We'll walk you through what to expect first — no email needed to get started.