Plain-English translation of NCT05777928 on ClinicalTrials.gov ↗ · Source last updated ·
This study doesn't follow the usual testing phases — it may be an observational study or a different type of research.
This trial is testing two approaches to help people with severe obesity lose weight and keep it off. Some participants will receive sleeve gastrectomy (a surgery that makes the stomach smaller), while others who previously had weight loss surgery and regained weight will receive a minimally invasive revision procedure using the OverStitch™ Endoscopic Suturing System (a technique that uses stitches to tighten the connection between the stomach and intestines without major surgery). The study measures how full people feel after eating to see if these procedures improve their sense of satiety.
About one-third of people who have bariatric surgery regain weight over time, often because the surgical connection in their stomach stretches out and they no longer feel as full when eating. This trial exists to see whether the OverStitch™ procedure—a less invasive way to tighten that connection—can restore the feeling of fullness and help prevent weight regain.
You likely qualify if…
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If you are in the sleeve gastrectomy group, you will receive that surgical procedure. If you are in the OverStitch™ group, you will receive a minimally invasive revision procedure to tighten your previous surgical connection. Before and after your procedure, you will participate in a Water Load Test—a simple, non-invasive test where you drink water until you feel pleasantly full, and researchers measure how much water you consume as an indicator of how satisfied you feel. The trial will track your sense of satiety and monitor your progress over time.
AI-generated summary from trial data · Jun 25, 2026 · Not medical advice
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