Plain-English translation of NCT05779423 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Phase 2 — Testing in a bigger group (up to a few hundred people) to see if the treatment actually works and is still safe.
This trial is testing a combination of three treatments for advanced melanoma (a serious type of skin cancer) that has stopped responding to earlier immune therapies. The study combines two FDA-approved immune-boosting medications— and —with a procedure called cryoablation, which freezes and removes tumors. Researchers want to see if using all three together is safe and more effective than the medications alone.
Many people with advanced melanoma eventually stop responding to standard immune-therapy drugs, leaving them with limited options. This trial explores whether adding a freezing procedure to the medications might help the immune system fight back harder against tumors that have become resistant.
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You would attend clinic visits to receive the two immune-boosting medications by IV infusion over several treatment cycles. Between the first and second cycles, you would undergo a needle biopsy (a small tissue sample) followed by the cryoablation procedure to freeze and remove one tumor. Throughout the study, you would have CT scans to monitor how your tumors are responding, blood draws, and follow-up visits to check for any side effects. The entire study could last up to 3 years, with the most intensive phase occurring during the first several months.
AI-generated summary from trial data · Jun 9, 2026 · Not medical advice
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