Plain-English translation of NCT05779423 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Phase 2 — Testing in a bigger group (up to a few hundred people) to see if the treatment actually works and is still safe.
This trial is testing a new combination approach for advanced melanoma that has stopped responding to earlier immune treatments. The study combines two FDA-approved immune-boosting medications ( and ) with a freezing procedure called cryoablation that destroys tumors. Researchers want to see if using all three together is safe and more effective than the medications alone.
Some patients with advanced melanoma find that their cancer stops responding to immune treatments over time, leaving them with limited options. This trial explores whether adding a freezing procedure to the immune-boosting medications might help restart the body's ability to fight the cancer.
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If you join this trial, you would receive four cycles of the two immune-boosting medications given by your doctor. Between the first and second cycles, you would undergo a biopsy (a small tissue sample) followed by the cryoablation procedure to freeze and remove one tumor. You would have CT scans to monitor your cancer, blood tests, and follow-up visits for at least 6 months after the freezing procedure to check for any side effects. The entire study involvement could last up to 3 years, depending on how well the treatment works and how long the benefit lasts.
AI-generated summary from trial data · Aug 31, 2026 · Not medical advice
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