Plain-English translation of NCT05783063 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Read our Schizophrenia research guide →This study doesn't follow the usual testing phases — it may be an observational study or a different type of research.
This trial is testing a treatment called intermittent theta burst stimulation (iTBS), which is a safe, non-invasive form of brain stimulation delivered to a specific area of the brain. The study is designed for people with schizophrenia who have experienced increased appetite and weight gain as a side effect of their antipsychotic medications. Researchers want to see whether this brain stimulation can help reduce appetite and food cravings while keeping the medications working well.
Many people taking antipsychotic medications experience unwanted increases in appetite and significant weight gain, which can lead to other health problems. There is a need for safe, additional treatments that can help control this side effect without requiring changes to the medications that are helping manage their schizophrenia symptoms.
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If you join this study, you will receive either active brain stimulation or a placebo (sham) stimulation to your forehead area. The treatment involves 5 short sessions per day for 5 consecutive days, with each session lasting about 3 minutes. You'll also complete questionnaires about appetite and mood, have some blood and stool samples collected, brain imaging scans, and cognitive tests at baseline, after treatment, and at follow-up visits 2 and 4 weeks later.
AI-generated summary from trial data · Jun 17, 2026 · Not medical advice
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