Can aggressive cholesterol treatment reverse heart plaque in young adults?

This trial is testing whether young adults with familial hypercholesterolemia—a genetic condition that causes very high cholesterol—can actually reverse the plaque buildup in their heart arteries by starting intensive cholesterol-lowering medication early. Researchers want to know if aggressive treatment can shrink existing plaque, not just prevent it from getting worse. This is important because it could change how doctors treat young people at high risk for heart disease.

Most heart disease treatments focus on stopping plaque from growing, but doctors don't know yet whether this medication can actually make existing plaque smaller in younger patients. This trial aims to answer that question and could help prevent heart attacks in people with genetic high cholesterol.