Plain-English translation of NCT05783817 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Phase 2 — Testing in a bigger group (up to a few hundred people) to see if the treatment actually works and is still safe.
This trial is testing whether MDMA, when combined with cognitive behavioral therapy (a type of talk therapy), can help reduce obsessive-compulsive disorder symptoms in people whose condition hasn't improved with standard treatments. You would receive the medication during therapy sessions designed to help you work through your OCD symptoms. The study will compare this approach with another similar treatment to see which works better.
OCD is a serious, lifelong condition that causes significant suffering and costs the healthcare system billions of dollars annually. Many people with OCD don't respond adequately to current standard treatments, so researchers are exploring whether this medication might help when combined with therapy.
You likely qualify if…
You likely don't qualify if…
You would attend sessions where you receive the medication and work with a therapist using cognitive behavioral therapy techniques to address your OCD. The medication would be given as pills — an initial dose followed by a smaller supplemental dose about 1.5 to 2 hours later. You would need to follow specific instructions like fasting before sessions and avoiding certain other medications. The study requires commitment to attending all sessions and following the treatment plan throughout the trial period.
AI-generated summary from trial data · Jul 8, 2026 · Not medical advice
United States
Phase
Testing effectiveness
Sponsor
Carolyn Rodriguez
Enrollment target
~40 participants
Started
September 2025
Primary completion
December 2026
Age range
18 Years and older
Last updated on clinicaltrials.gov in March 2026.
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Central contact
Alessa Gaeta, MS
Stanford University
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