Plain-English translation of NCT05785741 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Phase 1/2 — A combined trial that checks safety and dosing while also starting to look at whether the treatment works.
This is one of the first times this treatment has been tested in people.
This study is testing a new cancer medication called in people whose advanced cancers have stopped responding to standard treatments. Researchers want to find the safest and most effective dose of this medication, and also test whether it works better when combined with other approved cancer drugs like or . The trial will help doctors understand how well this treatment works and what side effects patients might experience.
Many people with advanced cancers run out of effective treatment options when their cancer stops responding to standard therapies. This medication aims to target cancer cells in a new way, and researchers hope it could help patients who have limited options left.
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You would receive the medication as an injection or infusion once every three weeks in cycles. The study starts with a Phase 1 portion where researchers carefully increase doses in small groups of patients to find the safest level, then moves to a Phase 2 expansion phase to test effectiveness in larger groups. You'll have regular blood tests, heart function tests, imaging scans, and clinic visits to monitor how you're responding and check for side effects. The study is expected to involve multiple visits over several months or longer, depending on how well the medication is working for you.
AI-generated summary from trial data · Jun 24, 2026 · Not medical advice
United States