Testing combination cancer drugs for rare tumors with specific genetic changes

This trial is testing whether two medications called trastuzumab and pertuzumab work together to treat rare cancers and uncommon types of common cancers that have a specific genetic change. The genetic change—called HER2 amplification or an activating HER2 mutation—is found in your tumor cells. Researchers want to see if this medication combination can help people whose cancers have this genetic marker.

Many people with rare cancers or cancers with rare genetic changes don't have good treatment options. This trial exists to find out whether this medication, already used for some cancers, might work for other cancers with the same genetic change—and eventually bring it to the NHS as a new treatment choice.