Testing a new drug combined with radiation for brain tumors

This trial is testing a combination approach to treat brain metastases (cancer that has spread to the brain). Researchers want to see whether combining a medication called azeliragon with stereotactic radiation therapy—a focused type of radiation that targets tumors precisely—can help tumors shrink better and stay controlled longer than radiation alone. The trial has two phases: first, doctors will figure out the safest way to combine the medication with radiation; then, they'll test whether this combination actually works.

Brain metastases are a serious complication of advanced cancer, and current treatments don't always work well enough. Researchers believe that this medication might make radiation therapy more effective by helping the brain respond better to treatment, potentially improving outcomes for patients with limited options.