How severe eczema affects the brain and mental health

This research study is trying to understand the hidden connections between severe eczema, sleep problems, and brain health in teenagers aged 12–18. Researchers will use brain scans, sleep monitoring devices, blood tests, and genetic analysis to explore whether the itching and sleepless nights caused by eczema can lead to inflammation in the brain and affect thinking and mood. The study will also track whether these problems improve when teenagers start new systemic medications that control eczema from the inside out.

Doctors know that teenagers with severe eczema often struggle with anxiety, depression, and trouble concentrating, but they don't fully understand why. This study aims to uncover whether the constant itching and disrupted sleep physically change the brain, so that better treatments and support can be developed.