Plain-English translation of NCT05790356 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
This study doesn't follow the usual testing phases — it may be an observational study or a different type of research.
This trial is testing a treatment called Fecal Microbial Transplantation (FMT) — essentially, a capsule containing healthy bacteria from a donor's gut — to see if it can help people with rheumatoid arthritis. Researchers believe that changing the mix of bacteria in your digestive system might reduce inflammation and improve how your immune system works. You would receive the treatment once, and then be monitored for 12 weeks to see if it helps.
Scientists have discovered that people with rheumatoid arthritis often have different bacteria in their gut compared to healthy people, and this difference may play a role in their disease. This trial is exploring whether restoring 'healthy' bacteria could be a new way to help control arthritis symptoms.
You likely qualify if…
You likely don't qualify if…
If you join, you'll have four visits over 12 weeks: a starting visit, a treatment visit where you'll take 35–40 capsules with water (taking about 30 minutes), and two follow-up visits at 6 and 12 weeks. At each visit, a rheumatologist will assess you, you'll fill out surveys about how you're feeling, and you'll provide blood, stool, and urine samples. Half of participants will receive the actual FMT treatment, and half will receive placebo capsules — neither you nor the researchers will know which you received until the study ends.
AI-generated summary from trial data · Jun 14, 2026 · Not medical advice
Canada
Sponsor
London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Collaborators
St. Joseph's Health Care London
Enrollment target
~30 participants
Started
August 2023
Primary completion
August 2025
This trial's estimated completion date has passed — the record may not be fully up to date.
Age range
18 Years and older
Last updated on clinicaltrials.gov in August 2024.
Reach out to the team running this trial. Response times vary — some teams are faster than others.
Central contact
Lillian Barra, MD, MPH
London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Tell us you're interested and we'll help connect you with the research team. We'll walk you through what to expect first — no email needed to get started.