Plain-English translation of NCT05791487 on ClinicalTrials.gov โ ยท Source last updated ยท Translation generated ยท How we translate trials
Read our Ulcerative Colitis research guide โThis study doesn't follow the usual testing phases โ it may be an observational study or a different type of research.
This trial is testing whether adding a specialized exclusion diet (called the UC Exclusion Diet) to budesonide medication can help people with ulcerative colitis achieve remission and heal their gut lining better than budesonide alone. The study will follow you for 24 weeks to see if the diet + medication combination works better than medication by itself. The hope is that dietary changes could treat the root cause of ulcerative colitis without requiring lifelong immune-suppressing drugs.
Right now, ulcerative colitis is only treated with medications or surgery, and many patients want alternatives that don't involve long-term immune suppression. This trial exists to see if a carefully designed diet might offer a gentler option that could actually address what causes the disease, rather than just managing symptoms.
You likely qualify ifโฆ
You likely don't qualify ifโฆ
You will be in this study for 24 weeks. If you are in the diet group, you will follow a specialized exclusion diet plus take budesonide medication for the first 6 weeks, then continue a modified phase 2 diet for weeks 7โ12, and a maintenance diet through week 24. The other group takes budesonide alone for 6 weeks with no dietary changes. Both groups will have a flexible sigmoidoscopy (a procedure to look inside your colon) at the start and again at week 12 to check for healing. You'll also continue any other maintenance medications you're already taking throughout the trial.
AI-generated summary from trial data ยท Jun 2, 2026 ยท Not medical advice
Israel
Italy
Netherlands