Plain-English translation of NCT05797467 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Read our Colorectal Cancer research guide →Phase 3 — Testing in thousands of people, comparing the treatment against what doctors currently use. This is the last big step before approval.
This study compares two treatment approaches for people who have had surgery for advanced colorectal cancer (specifically, a type called stage T3-4N2). Half of the participants will receive standard chemotherapy alone, while the other half will receive chemotherapy combined with targeted therapy — a medication designed to attack cancer cells in a specific way. The trial wants to see whether adding this targeted medication helps people stay cancer-free longer.
Advanced colorectal cancer has a high risk of coming back even after surgery and chemotherapy. Doctors believe that the medication might improve outcomes by targeting cancer cells more precisely, and this trial will test whether that benefit is real.
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If you join this trial, you will be randomly assigned to receive either chemotherapy alone or chemotherapy combined with targeted therapy. You will visit the hospital regularly for your treatment and monitoring over the course of several months. Your doctors will check your health with blood tests and scans to see how you are responding and to watch for any side effects. The trial team will follow you to track whether your cancer stays away.
AI-generated summary from trial data · Jun 12, 2026 · Not medical advice
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