Plain-English translation of NCT05799144 on ClinicalTrials.gov ↗ · Source last updated · Translation generated ·
Phase 2 — Testing in a bigger group (up to a few hundred people) to see if the treatment actually works and is still safe.
This trial is testing whether two experimental vaccines (pBI-11 and TA-HPV) work better when combined with , a drug that helps your immune system fight cancer. The vaccines are designed to train your body to recognize and attack HPV-positive cancer cells. Researchers want to see if this combination is safe and whether it helps shrink or slow advanced throat cancer that has returned or spread to other parts of the body.
People with advanced HPV-related throat cancer often have limited treatment options, and many don't respond well to standard therapies. This medication () alone helps some patients, but researchers believe that adding these custom vaccines might boost your immune system's ability to fight the cancer more effectively.
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You will receive two vaccine injections and an intravenous infusion of on a regular schedule during the trial. You'll have CT or MRI scans and blood tests done during screening and throughout the study to monitor how your cancer responds and check for side effects. You may also have a tumor biopsy at the start or during the trial to help doctors understand how the treatment is working at the cellular level.
AI-generated summary from trial data · Jun 30, 2026 · Not medical advice
United States