Plain-English translation of NCT05800457 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
This study doesn't follow the usual testing phases — it may be an observational study or a different type of research.
This trial is testing whether removing the inflamed lining of the knee joint (called the synovium) during total knee replacement surgery can help reduce pain after surgery. About 20% of people who have knee replacement surgery remain unhappy with their results because of ongoing pain—this study aims to see if removing this inflamed tissue first can make a real difference in how much pain patients experience.
Even after knee replacement surgery, some patients continue to suffer from significant pain caused by inflammation in the joint. This trial wants to find out if removing the source of that inflammation during surgery could provide even better pain relief and help researchers develop better long-term treatments for joint pain.
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If you join this study, you will undergo total knee replacement surgery—and randomly be assigned to either have your inflamed joint lining removed during surgery or not. Before and after your surgery, you will complete questionnaires about your pain and how well your knee functions, perform some physical tests, and rate your quality of life. Your progress will be tracked at routine post-surgery follow-up visits to see how well each approach works for pain relief.
AI-generated summary from trial data · Jun 12, 2026 · Not medical advice
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