Plain-English translation of NCT05801380 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Read our Alzheimer Disease research guide →This research study is tracking how well two different Alzheimer's medication strategies work in people who have just been diagnosed with mild to moderate Alzheimer's disease. Some participants will take a single medication called an acetylcholinesterase inhibitor, while others will take a combination of an acetylcholinesterase inhibitor and another medication called an NMDA receptor antagonist. The study will monitor how well these treatments help over six months by checking in at baseline, three months, and six months.
Doctors want to understand whether combining two types of Alzheimer's medications works better than using just one medication alone. By comparing how people respond to each approach, researchers hope to find the most effective way to slow memory loss and help people with Alzheimer's.
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You will visit the research clinic at baseline (start), three months, and six months. At each visit, researchers will assess how your memory and thinking are doing and check how well the medication is working for you. Your doctor will have already prescribed you one of the two medication approaches based on standard clinical care, and the study will simply monitor your response to whichever treatment you're receiving. The study lasts six months total.
AI-generated summary from trial data · Jun 13, 2026 · Not medical advice
Philippines
Sponsor
University of the Philippines
Enrollment target
~60 participants
Started
February 2022
Primary completion
February 2026
This trial's estimated completion date has passed — the record may not be fully up to date.
Age range
65 Years and older
Last updated on clinicaltrials.gov in January 2025.
Reach out to the team running this trial. Response times vary — some teams are faster than others.
Central contact
Fresthel Monica M Climacosa, MD, PhD
University of the Philippines Manila
Tell us you're interested and we'll help connect you with the research team. We'll walk you through what to expect first — no email needed to get started.