Brain Training to Reduce Mood Symptoms in Bipolar Disorder

This trial is testing a novel brain-training approach called real-time fMRI neurofeedback for people with bipolar disorder who experience lingering depressive symptoms between mood episodes. During the training, you'll look at emotional images while receiving immediate feedback about your brain's activity, helping you learn to better regulate your emotional responses. The goal is to reduce sadness and emotional sensitivity that don't fully go away even when your mood is otherwise stable.

Many people with bipolar disorder continue to feel depressed or emotionally reactive even when they're not having a major mood episode, and current medications and therapy don't fully address these lingering symptoms. This trial explores whether training your brain to regulate emotions differently could help fill that treatment gap.