Plain-English translation of NCT05804591 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Read our Obesity research guide →Phase 4 — The treatment has already been approved. Researchers are tracking how it works in a large number of people over time.
This trial is testing whether pregabalin, a medication that helps with pain and anxiety, can be given before weight-loss surgery to help patients feel better after the operation. Researchers believe that taking this medication before surgery—as part of a complete pain-management plan—might reduce pain and the need for opioid painkillers (strong narcotic medications that can have bothersome side effects). The study will compare patients who receive the medication before surgery with those who receive a placebo (a dummy pill).
Patients having weight-loss surgery often experience significant pain afterward and may need large amounts of opioid medications, which can cause nausea, drowsiness, and other unwanted effects. This trial is exploring whether this medication could help manage pain better with fewer of these side effects.
You will be randomly assigned to receive either the medication or a placebo one hour before your scheduled weight-loss surgery. Both groups will receive standard pain management during and after surgery. Your pain levels, nausea, medication use, and how your body responds during surgery will be carefully monitored and recorded. You'll be asked to rate your pain using standard scales so researchers can compare how well the medication works compared to placebo.
AI-generated summary from trial data · Jun 11, 2026 · Not medical advice
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