Stem cell transplant with gentler conditioning and cyclophosphamide for blood cancers

Plain-English translation of NCT05805605 on ClinicalTrials.gov ↗ · Source last updated July 2026 · Translation generated July 2026 · How we translate trials

Phase 2 — Testing in a bigger group (up to a few hundred people) to see if the treatment actually works and is still safe.

What is this trial?

This trial is testing a stem cell transplant approach for people with blood cancers and related disorders. You would receive a gentler preparatory regimen (chemotherapy and radiation) followed by stem cells from a donor, combined with post-transplant to help protect you from complications. The goal is to determine if this gentler approach can successfully treat your condition while reducing severe side effects.

Standard stem cell transplants can be very hard on the body. This trial exists to see if a less intensive preparation method combined with post-transplant can work just as well while being easier to tolerate, especially for older patients or those who might not survive a more intense transplant.

Do you qualify?

You likely qualify if…

you are between 0 and 75 years old and in good enough overall health (your doctor will assess this)
you have been diagnosed with one of the eligible blood cancers or bone marrow disorders, such as acute leukemia, chronic myelogenous leukemia, lymphoma, or myelodysplastic syndrome
your leukemia or lymphoma is in remission (under control) with very few or no cancer cells detectable
you have access to a matched or partially matched stem cell donor—a relative, unrelated volunteer, or partially matched family member
you have not had a previous stem cell transplant

You likely don't qualify if…

you have a severe infection that is currently untreated or uncontrolled
you have significant organ damage (heart, lung, liver, or kidney problems) that your doctor believes would make transplant too risky
you are pregnant or breastfeeding
you have a favorable-risk acute myeloid leukemia in first remission and are under 60 years old (unless you cannot tolerate standard chemotherapy)

What participation looks like

You would be admitted to the hospital for several weeks. First, you'll receive chemotherapy and whole-body radiation to prepare your body for the new stem cells. Then you'll receive stem cells from your donor through an infusion (like a blood transfusion). After transplant, you'll receive and other medications to prevent rejection and complications. You'll stay in or near the hospital for close monitoring, with frequent blood tests and check-ins. Recovery continues for months after you leave the hospital, with ongoing clinic visits to watch for side effects and ensure the transplant is working.

AI-generated summary from trial data · Jul 16, 2026 · Not medical advice

Trial locations(1 site)

United States

Masonic Cancer Center at University of Minnesota, Minneapolis, Minnesota