Plain-English translation of NCT05813093 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Read our Major Depressive Disorder research guide →This study doesn't follow the usual testing phases — it may be an observational study or a different type of research.
This trial tests a type of magnetic brain stimulation called theta-burst stimulation (TMS) in people with severe depression that has not improved with multiple medications and other treatments. Researchers will use advanced brain imaging called fMRI while delivering the stimulation to see how the treatment changes brain activity and which patients are most likely to benefit. This will help doctors better understand how this treatment works and improve the way it's delivered.
Some people with depression don't respond to standard treatments like antidepressant medications or therapy, and they need new options. This trial is designed to unlock how magnetic brain stimulation actually changes the brain's activity patterns, so doctors can predict which patients will improve and make the treatment even more effective.
You likely qualify if…
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You will start with brain imaging scans (fMRI) while receiving magnetic stimulation to measure your baseline brain activity. Then you will receive an accelerated course of the magnetic stimulation treatment over 5 consecutive days, with the stimulation targeted to the specific brain region identified from your baseline scans. Throughout the study, you'll complete mood and function questionnaires before, during, and after treatment to help researchers understand how well the treatment works for you.
AI-generated summary from trial data · Jul 17, 2026 · Not medical advice
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