Plain-English translation of NCT05815082 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Read our Colorectal Cancer research guide →Phase 3 — Testing in thousands of people, comparing the treatment against what doctors currently use. This is the last big step before approval.
After surgery to remove colorectal cancer that has spread to the liver, doctors will perform a special blood test called ctDNA testing to check for any remaining cancer cells. If this test shows no cancer cells, you will be randomly assigned to either receive chemotherapy (such as oxaliplatin-based regimens or 5-FU) or to a "watch and wait" approach where you are closely monitored without chemotherapy. The trial will compare whether both groups have similar cancer-free survival rates over three years.
Chemotherapy after liver cancer surgery can be harsh and has significant side effects. Researchers want to know if patients whose blood tests show no remaining cancer can safely skip this medication and simply be monitored closely instead, without their cancer returning faster.
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After your liver surgery, you will have a blood test to check for remaining cancer cells. If the test is negative, you will be randomly assigned to one of two groups: either receive chemotherapy treatments over several months, or have regular follow-up appointments and scans to watch for any cancer return. The trial will track your health and cancer status for three years to compare how well each approach works.
AI-generated summary from trial data · Jun 12, 2026 · Not medical advice
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