Plain-English translation of NCT05816603 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Phase 2 — Testing in a bigger group (up to a few hundred people) to see if the treatment actually works and is still safe.
This study is testing transcranial direct current stimulation (tDCS)—a non-invasive procedure that uses mild electrical current to stimulate a specific brain region—as a home-based treatment for severe fatigue after stroke. Half of the participants will receive the real treatment, and half will receive a sham (inactive) version so researchers can compare results fairly. The goal is to see whether this treatment can help people recover more energy and improve their quality of life after stroke.
Fatigue is one of the most common and disabling problems people face after a stroke, but there are few effective treatments available. This trial investigates whether this non-medication approach could offer patients a new way to manage this exhausting symptom.
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You would use a small brain stimulation device at home for 20 minutes once daily over two weeks—that's 14 sessions total. Each session requires a caregiver or friend to be present. You'll have check-in assessments after the 7th session, after the 14th session, and again one month after starting. The study also includes brain imaging (scans) at the beginning and end to help researchers understand how the treatment works.
AI-generated summary from trial data · Jun 13, 2026 · Not medical advice
United States
Phase
Testing effectiveness
Sponsor
Weill Medical College of Cornell University
Collaborators
American Heart Association
Enrollment target
~24 participants
Started
May 2023
Primary completion
December 2027
Age range
18 Years and older
Last updated on clinicaltrials.gov in February 2026.
Reach out to the team running this trial. Response times vary — some teams are faster than others.
Central contact
Zhiyan Yang, M.A.
Weill Medical College of Cornell University
Tell us you're interested and we'll help connect you with the research team. We'll walk you through what to expect first — no email needed to get started.