Plain-English translation of NCT05816798 on ClinicalTrials.gov ↗ · Source last updated ·
Phase 3 — Testing in thousands of people, comparing the treatment against what doctors currently use. This is the last big step before approval.
This study is testing photobiomodulation—a safe, painless treatment that uses low-intensity laser light—to help reduce chronic knee pain in people with severe obesity who are getting ready for weight loss surgery. Half of the participants will receive the real light therapy combined with standard physical therapy exercises, and half will receive a placebo (fake) light therapy with the same exercises. The goal is to see whether the light therapy helps people manage their knee pain better and participate more fully in their pre-surgery rehabilitation program.
Chronic knee pain affects about 80% of people with severe obesity and often prevents them from doing the physical therapy exercises needed before surgery—which can lead to more complications after the operation. This trial is testing whether this treatment can safely reduce pain and help people become stronger and more active before their procedure.
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You will come to the clinic 2 times per week for 12 weeks. During each visit, you will receive light therapy applied to specific points on your knees and lower back (either real or placebo, depending on which group you are in), followed by standard physical therapy exercises. The light therapy sessions take about 10–15 minutes, and you will wear protective eyewear. You will also complete questionnaires about your pain and quality of life at the beginning, during, and at the end of the study.
AI-generated summary from trial data · Jul 10, 2026 · Not medical advice
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