Plain-English translation of NCT05818319 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
This study doesn't follow the usual testing phases — it may be an observational study or a different type of research.
Cystic fibrosis affects how your kidneys handle certain substances in your urine. This study is testing whether elexacaftor/tezacaftor/ivacaftor—a medication you may already be taking for cystic fibrosis—is actually working by measuring changes in your urine when you briefly pause the medication. By studying what happens during these short pauses, researchers hope to develop a simple urine test that shows how well this treatment is controlling your cystic fibrosis at the kidney level.
Currently, there's no easy way to measure whether this medication is working in your kidneys specifically. If researchers can identify a reliable urine marker, it could help doctors monitor your treatment more effectively and personalize your care.
You likely qualify if…
You likely don't qualify if…
You will pause your cystic fibrosis medication for either 12, 36, or 60 hours while researchers collect urine samples before, during, and after the pause. This allows them to measure how your kidneys respond when the medication is stopped and restarted. The study involves visits to provide samples and have your kidney function monitored during these short medication breaks.
AI-generated summary from trial data · Jun 8, 2026 · Not medical advice
Denmark
Sponsor
University of Aarhus
Enrollment target
~30 participants
Started
June 2023
Primary completion
December 2025
This trial's estimated completion date has passed — the record may not be fully up to date.
Age range
18 Years and older
Last updated on clinicaltrials.gov in February 2025.
Reach out to the team running this trial. Response times vary — some teams are faster than others.
Central contact
Amalie Q. Rousing, BM
Department of Biomedicine, Aarhus University, Denmark
Tell us you're interested and we'll help connect you with the research team. We'll walk you through what to expect first — no email needed to get started.