Plain-English translation of NCT05819931 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
This study doesn't follow the usual testing phases — it may be an observational study or a different type of research.
This trial is testing a device called a mechanical in-exsufflator, which helps people with ALS who have weak coughs. The device uses gentle pressure to help clear the lungs and improve breathing. Researchers want to see if regular sessions with this device over 4 weeks can strengthen coughing ability in ALS patients.
People with ALS gradually lose control of their muscles, including those needed for coughing and breathing. A weak cough can lead to serious complications like infections. This trial exists to see if this breathing device can help patients maintain better lung health and reduce breathing problems.
You likely qualify if…
You likely don't qualify if…
If you join this study, you will use the mechanical in-exsufflator device with your physiotherapist's help. For the first two weeks, you'll have 3 sessions per week; for the next two weeks, you'll have one daily session. Your coughing ability will be measured before and after the 4-week treatment period to see if the device helps improve your breathing.
AI-generated summary from trial data · Jun 1, 2026 · Not medical advice
France
University Hospital, Toulouse
Enrollment target
~36 participants
Started
August 2023
Primary completion
December 2026
Age range
18 Years – 100 Years
Last updated on clinicaltrials.gov in May 2026.
Reach out to the team running this trial. Response times vary — some teams are faster than others.
Central contact
Thierry LAGARDE, PT
University Hospital, Toulouse
Tell us you're interested and we'll help connect you with the research team. We'll walk you through what to expect first — no email needed to get started.