Plain-English translation of NCT05821010 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Phase 2 — Testing in a bigger group (up to a few hundred people) to see if the treatment actually works and is still safe.
This trial is testing whether a combination of beneficial gut bacteria capsules (called lyophilized fecal microbiota transplantation capsules) along with supplements called prebiotics and probiotics can help reduce fatty liver disease and prevent scarring. The study will compare this medication against a placebo (dummy pill) to see if the real treatment works better. Researchers think that improving your gut bacteria may help your liver heal.
Many people develop fatty liver disease unrelated to alcohol, which can lead to scarring and serious liver damage over time. Currently, there are limited treatment options available, so researchers want to test whether improving gut bacteria through this medication could help reduce liver inflammation and prevent progression.
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You will take capsules and supplements for 24 weeks (about 6 months). At the start, you'll take a daily supplement, then receive large batches of capsules at three timepoints (weeks 0, 8, and 16) and continue taking a few capsules daily throughout the study. You'll have study visits roughly every 8 weeks where researchers will check on your health and collect blood samples to monitor your liver. Half the participants will receive the real treatment and half will receive placebo, but neither you nor the researchers will know which you're receiving during the study.
AI-generated summary from trial data · Jun 3, 2026 · Not medical advice
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