Testing a Nerve-Blocking Procedure for Heart Failure and High Lung Pressure

This trial is testing a new procedure called pulmonary artery denervation (PADN), which uses radiofrequency energy to block nerves in blood vessels of the lungs. The procedure is being tested in people who have heart failure and also have abnormally high pressure in their lung blood vessels, even though they are already taking heart failure medications. Researchers want to see if this procedure, when added to standard heart failure treatment, can improve how patients feel and function.

Many people with heart failure develop high pressure in their lung blood vessels, which makes their symptoms worse and limits their activities. Current medications help, but not enough for some patients. This trial exists to see whether blocking these nerves can reduce lung pressure and improve quality of life for people who aren't getting enough relief from medications alone.