Testing two drug combinations to personalize treatment for lung high blood pressure

Plain-English translation of NCT05825417 on ClinicalTrials.gov ↗ · Source last updated June 2026 · Translation generated June 2026 · How we translate trials

Phase 4 — The treatment has already been approved. Researchers are tracking how it works in a large number of people over time.

What is this trial?

This study tests whether and —two medications approved to treat high blood pressure in the lungs—can help you when added to or switched with your current treatment. You'll receive a small implanted device that monitors your heart and lung pressures remotely, then try different combinations of medications over several months to see which works best for you personally.

Many people with high blood pressure in the lungs don't improve enough with standard treatment alone. This trial aims to find out whether trying different medication combinations in a personalized way—and using remote heart monitoring to track your response—can help doctors choose the right treatment for each individual patient.

Do you qualify?

You likely qualify if…

you are between 18 and 80 years old
you have been diagnosed with pulmonary arterial hypertension that is idiopathic, inherited, or caused by drugs, toxins, or connective tissue disease
you have been stable on a combination of two standard lung blood pressure medications for at least one month
you are in WHO functional class III (moderate activity limitation due to your condition)
you have not responded adequately to your current treatment, as determined by your doctor
you can walk more than 50 meters in a 6-minute walk test

You likely don't qualify if…

you are pregnant or planning to become pregnant
you have a history of unprovoked blood clots in the lungs
you have significant kidney disease or very low hemoglobin (severe anemia)
you cannot take aspirin or similar blood-thinning medications, or you are allergic to selexipag or riociguat
you have other forms of pulmonary hypertension (such as from left heart disease, lung disease, or blood clots) rather than pulmonary arterial hypertension

What participation looks like

You will first have a small device implanted in your chest that monitors your heart and lung pressures wirelessly. Then you'll spend about 6 months in the study, visiting the clinic regularly as your doctors switch you between two different medication regimens—increasing doses gradually, then reducing them—while tracking how you respond. You'll have heart imaging (MRI), blood tests, walking tests, and heart pressure measurements at key time points to help doctors understand which combination works best for you.

AI-generated summary from trial data · Jun 8, 2026 · Not medical advice

Testing two drug combinations to personalize treatment for lung high blood pressure

What is this trial?

Do you qualify?

What participation looks like

Trial locations(1 site)