Plain-English translation of NCT05838274 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
This study doesn't follow the usual testing phases — it may be an observational study or a different type of research.
Researchers are studying how young adults respond to alcohol — both in their brain activity and their feelings — to better understand why some people develop alcohol-related problems. The study compares young adults with bipolar disorder to those without bipolar disorder, using brain scans and carefully controlled doses of alcohol (or a placebo drink that looks and tastes similar) given in a safe, supervised setting. By following participants for two years and repeating these tests, the team hopes to identify early warning signs that could help prevent alcohol use disorders.
Young adults with bipolar disorder may be at higher risk for developing alcohol use disorders, but we don't fully understand why. This study aims to identify biological and behavioral patterns that could help predict and prevent these problems before they start.
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You would visit the research clinic multiple times over two years. At each visit, you'll have brain imaging scans (MRI) while resting, complete questionnaires about your mood and drinking, and then participate in a controlled session where you'll drink either a small amount of alcohol or a placebo beverage while your brain activity is monitored. Some participants will also complete stress-related brain imaging tasks. Follow-up visits occur around 1 year and 2 years after enrollment, repeating some of these tests to see how your brain's response to alcohol changes over time.
AI-generated summary from trial data · Jun 8, 2026 · Not medical advice
United States