Plain-English translation of NCT05838391 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
This study doesn't follow the usual testing phases — it may be an observational study or a different type of research.
This study is testing a new approach to radiation therapy for people with locally advanced anal cancer. Instead of using the same radiation plan for all six weeks of treatment, doctors will adjust the plan daily based on scans taken during each treatment session. You'll also receive standard chemotherapy ( and ) at the same time, which is already the proven treatment for this type of cancer.
During radiation treatment, anal cancers often shrink noticeably within the first week or two. Currently, doctors don't routinely adjust treatment plans to account for this shrinkage because it takes extra time and resources. This trial is testing whether daily-adjusted radiation could be more efficient and potentially more effective by treating the tumor as it actually is, rather than as it was at the start of therapy.
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You will come to the hospital or cancer center five days a week for six weeks. At each session, you'll receive a CT scan on the radiation machine to create a customized treatment plan for that specific day, followed by your radiation therapy. Separately, you'll receive chemotherapy infusions or oral medication on specific days during the first and fifth weeks of treatment. Throughout the trial, your doctor will monitor your health with blood tests and check-in visits to watch for side effects.
AI-generated summary from trial data · Jun 6, 2026 · Not medical advice
United States