Plain-English translation of NCT05838573 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Read our Schizophrenia research guide →Phase 3 — Testing in thousands of people, comparing the treatment against what doctors currently use. This is the last big step before approval.
This trial is testing whether metformin—a medication commonly used to treat diabetes—can help improve thinking, memory, and cognitive problems in people living with schizophrenia. About 120 people will participate, with some receiving the medication and others receiving a placebo (an inactive pill) over 24 weeks. Researchers will measure changes in cognitive function using standardized tests and brain imaging.
People with schizophrenia often experience difficulties with memory and thinking that can make daily life harder. This medication has shown promise in early research for helping with these cognitive problems, but researchers need a larger, carefully controlled study to confirm whether it truly works and is safe for this population.
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Over 24 weeks, you would visit the research clinic three times: at the start, at 12 weeks, and at 24 weeks. At each visit, you would have physical exams, blood tests, brain scans, and complete thinking/memory tests. You would take either the study medication or a placebo pill daily at home, while continuing your regular schizophrenia medications. The research team would monitor your health and any side effects throughout the study.
AI-generated summary from trial data · Jun 2, 2026 · Not medical advice
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