Combining a skin cream with radiation therapy for cutaneous T-cell lymphoma

This early-phase trial is testing a combination approach using imiquimod—a topical cream that boosts the immune system—paired with focused radiation therapy to treat mycosis fungoides, a rare skin cancer of white blood cells. The idea is that the cream prepares your immune system before radiation is given, potentially making the radiation more effective. Researchers want to see if this two-pronged approach is safe and works better than either treatment alone.

Mycosis fungoides is difficult to treat, especially when it advances or returns after initial therapy. While radiation therapy and immune-stimulating creams are both used separately, doctors want to explore whether combining them might enhance the immune system's ability to fight the cancer more effectively.