Plain-English translation of NCT05840562 on ClinicalTrials.gov ↗ ·
Phase 3 — Testing in thousands of people, comparing the treatment against what doctors currently use. This is the last big step before approval.
Chemotherapy can damage nerves in your hands and feet, causing pain, numbness, and tingling that lasts long after treatment ends. This study is testing whether a patch—a treatment made from chili peppers that blocks pain signals—works as well as or better than , an oral medication that is currently the only recommended drug for this type of nerve pain.
is the only medication officially recommended for this nerve pain, but many patients experience side effects and stop taking it. Early research suggests the medication works well, but no study has directly compared how well it performs against the patch, which may have fewer side effects.
You likely qualify if…
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You will be randomly assigned to receive either the patch or take pills by mouth. If you receive the patch, it will be applied to your most painful areas for 30–60 minutes, and you may need multiple sessions over a few days; treatment can be repeated every 2 months if your pain returns. If you take the medication, you'll start with a lower dose for one week, then move to a maintenance dose of 60 mg daily. You will visit the study center multiple times over 6 months so the doctors can track how well your pain improves and check for any side effects.
AI-generated summary from trial data · Jun 1, 2026 · Not medical advice
France