Plain-English translation of NCT05841420 on ClinicalTrials.gov โ ยท Source last updated ยท Translation generated ยท How we translate trials
Phase 2 โ Testing in a bigger group (up to a few hundred people) to see if the treatment actually works and is still safe.
This trial is testing whether a lower dose of combination chemotherapy (two medications given together) works better and is safer than a single chemotherapy medication for older or frailer patients with pancreatic cancer that cannot be removed by surgery. Currently, standard treatment guidelines recommend combination chemotherapy for most patients, but doctors often offer only single-agent to elderly or frail patients because the combination can be harder to tolerate. This study wants to see if the combination medication at a reduced dose might actually help these patients live longer without causing more harm.
Older and frail patients with advanced pancreatic cancer have not had good treatment options, and studies in other cancers suggest that a lower dose of combination therapy might work better than single-agent treatment in these groups. Recent evidence also suggests that using combination chemotherapy more often could improve survival, but no one has formally tested whether a reduced dose is safe and effective for patients too weak for full-strength combination treatment.
You likely qualify ifโฆ
You likely don't qualify ifโฆ
You will be randomly assigned to receive either a single chemotherapy medication () at full dose once a week, or a combination of two medications at a lower dose once a week. Both treatment schedules follow a 4-week cycle, with injections given on days 1, 8, and 15 of each cycle. You will attend regular clinic visits for blood tests, physical exams, and imaging scans to monitor how the treatment is working and to watch for side effects. The study involves about 98 patients across multiple hospitals in Denmark and will last several months to years depending on how your cancer responds.
AI-generated summary from trial data ยท Jun 24, 2026 ยท Not medical advice
Denmark