Recruiting

Helping people with HIV and TB quit smoking

Plain-English translation of NCT05842161 on ClinicalTrials.gov ↗ · Source last updated April 2026 · Translation generated June 2026 · How we translate trials

This study doesn't follow the usual testing phases — it may be an observational study or a different type of research.

What is this trial?

This trial is testing QUIT-AD, a counseling program designed to help people quit smoking while managing HIV and TB. The program uses cognitive-behavioral therapy—a type of talk therapy that helps change how you think about smoking and stress—combined with practical strategies to stay motivated. Researchers hope this approach will help people quit smoking and stick with their HIV and TB medications.

Smoking is extremely common among people with HIV and TB in South Africa and makes both conditions much worse. People who smoke are more likely to progress to AIDS, have harder-to-treat TB, and develop serious lung disease. There is an urgent need for a program that addresses smoking while also helping people stay committed to their life-saving HIV and TB treatments.

Do you qualify?

You likely qualify if…

you are 18 years old or older
you have been diagnosed with HIV and are taking antiretroviral therapy, or you started or restarted TB treatment in the past month
you smoke more than 5 cigarettes per day
you are motivated to quit smoking (rating your motivation 5 or higher on a 10-point scale, or you've tried to quit for at least 24 hours in the past year)
you are willing and able to give written informed consent

You likely don't qualify if…

you regularly use other tobacco products besides cigarettes
you have an untreated or unstable mental health condition like psychosis or bipolar disorder
you are currently taking other medications to help quit smoking
you started cognitive-behavioral therapy for smoking cessation within the past year
you have been diagnosed with drug-resistant TB or TB outside the lungs

What participation looks like

If you are randomly assigned to the main program, you will attend six counseling sessions where you'll learn strategies to quit smoking, manage stress, and stay engaged with your HIV and TB care. If you are assigned to the comparison group, you'll receive one educational session about the health benefits of quitting smoking. Participants will be asked to track their smoking and treatment progress throughout the study.

AI-generated summary from trial data · Jun 6, 2026 · Not medical advice

Trial locations(1 site)

South Africa

University of Cape Town, Rondebosch