Plain-English translation of NCT05849402 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
This study doesn't follow the usual testing phases — it may be an observational study or a different type of research.
This study is testing a treatment called accelerated intermittent theta-burst stimulation (aiTBS), which uses magnetic pulses to gently stimulate a specific area of the brain involved in mood regulation. The goal is to see whether this noninvasive procedure can help reduce depressive symptoms in people with bipolar II disorder who have not improved with medications alone. Researchers will also measure how the brain's connections change in response to the treatment.
Many people with bipolar II disorder continue to struggle with depression even after trying multiple medications. This trial exists to explore whether brain stimulation offers a new option for those whose depression hasn't gotten better with standard treatments.
If you join this trial, you will receive 10 brain stimulation sessions over 5 consecutive days (2 sessions per day). Before and after the treatment period, you'll have MRI brain scans, brain wave recordings, and heart rate measurements. Some participants will receive the active stimulation, while others will receive a sham (placebo) version—neither you nor the researchers will know which until the end. You'll also complete questionnaires about your mood and depression symptoms at several points during the study.
AI-generated summary from trial data · Jul 7, 2026 · Not medical advice
United States