Plain-English translation of NCT05855603 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
This study doesn't follow the usual testing phases — it may be an observational study or a different type of research.
This trial is testing two different treatments for a type of fainting spell caused by an overactive nerve reflex in your heart and body. You would be randomly assigned to receive either a dual-chamber pacemaker (a small device implanted under your skin to regulate your heartbeat) or cardioneuroablation (a catheter-based procedure that uses targeted heat to calm overactive nerve pathways in your heart). Both treatments aim to prevent the sudden drops in heart rate and blood pressure that trigger your fainting episodes.
While pacemakers have been used for years to help people with severe fainting spells, a newer technique called cardioneuroablation has shown promise in small studies and may offer an alternative without implanting a device. This trial compares both approaches fairly to see which works better for preventing fainting and improving quality of life.
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If you enroll, you will be randomly assigned to one of two groups: either receiving a pacemaker implant procedure or undergoing cardioneuroablation. Both are performed at specialized heart centers. You will then be followed by the research team to see how well your treatment works in preventing fainting spells and whether it improves your daily life. The study involves about 90 total participants across multiple medical centers, and you would be monitored to track how often fainting episodes occur after treatment.
AI-generated summary from trial data · Jul 4, 2026 · Not medical advice
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