Plain-English translation of NCT05855954 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
This study doesn't follow the usual testing phases — it may be an observational study or a different type of research.
After heart surgery, some patients develop acute kidney injury—a serious complication that can mean longer hospital stays and worse outcomes. This trial is testing whether a technique called controlled low central venous pressure (CLCVP) can prevent kidney damage by managing fluid and blood pressure carefully during surgery. The technique uses medications like nitroglycerin, positioning changes, and fluid management to keep blood flowing smoothly and prevent dangerous blood backup in the veins.
Doctors have noticed that during heart surgery, a backup of blood in the veins (venous congestion) can harm the kidneys more than low blood pressure does. This trial exists to see if keeping venous pressure lower during surgery—using proven, safe methods—can actually protect kidney function and reduce the serious complications that often follow cardiac surgery.
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If you are in the treatment group, after your heart surgery is complete and you're coming off the heart-lung machine, the surgical team will position you slightly upright and gradually give you nitroglycerin medication to gently lower the pressure in your veins. They will monitor a pressure measurement called central venous pressure and adjust the medication until that pressure reaches a safe target, which they will maintain until surgery ends. The control group receives standard care without this special blood pressure management technique. After surgery, both groups will be monitored for signs of kidney injury.
AI-generated summary from trial data · Jun 10, 2026 · Not medical advice
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